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    Protect yourself from typhoid fever before international travel by getting vaccinated. Learn about vaccine options, who should be vaccinated, and how to reduce risk through safe food and water practices.

    Typhoid vaccines are recommended for travelers to high-risk regions.

    Vaccines are not 100% effective—safe eating is essential.

    Two types: oral live vaccine and injectable killed vaccine.

    Typhoid fever is a serious, potentially life-threatening illness caused by bacteria found in contaminated food or water. Although rare in the U.S., it’s common in parts of Asia, Africa, and Latin America. Fortunately, typhoid vaccines offer protection for travelers and others at risk.

    What is typhoid fever?

    Typhoid fever is a serious bacterial infection caused by the bacterium Salmonella enterica serotype Typhi (S. Typhi). It is primarily transmitted through contaminated food and water, often in areas with poor sanitation. Once ingested, the bacteria invade the intestinal walls and can enter the bloodstream, leading to systemic infection. Symptoms typically include prolonged fever, weakness, abdominal pain, headache, and loss of appetite. If left untreated, typhoid fever can result in severe complications and can be life-threatening.

    Vaccination is an effective way to prevent typhoid fever, according to the CDC — especially for individuals traveling to regions where the disease is prevalent. Treatment usually involves antibiotics, although antibiotic resistance is becoming an increasing concern. Prompt medical attention is important for a full recovery, and maintaining good hygiene practices, such as proper handwashing and safe food preparation, can significantly reduce the risk of infection.

    What is the typhoid fever vaccine?

    What is the typhoid fever vaccine?

    The typhoid fever vaccine is designed to protect against infection by Salmonella enterica serotype Typhi, the bacterium responsible for typhoid fever. There are two main types of vaccines available: the inactivated (killed) vaccine, which is administered as an injection, and the live attenuated vaccine, which is given orally. The injectable vaccine is typically recommended for adults and children over the age of two, while the oral vaccine is suitable for individuals aged six years and older.

    The injectable vaccine provides protection for about two years, while the oral vaccine requires a series of doses taken over several days and offers protection for approximately five years. Regular booster doses are recommended for those at continued risk of exposure.

    Who should get a typhoid fever vaccine?

    According to the CDC, typhoid vaccination is recommended for people at higher risk of exposure to Salmonella Typhi, the bacteria that causes typhoid fever. This includes:

    • International travelers going to countries where typhoid fever is common, such as parts of Asia (especially India, Pakistan, Bangladesh), Africa, the Caribbean, Central and South America, and the Middle East.
    • People in close contact with someone who is actively infected or a chronic carrier of the bacteria.
    • Laboratory workers who handle Salmonella Typhi bacteria.

    It’s best to get vaccinated at least 2–3 weeks before travel. Talk to a healthcare provider to determine if you need the oral or injectable vaccine.

    How effective is the vaccine?

    Typhoid fever vaccines are effective, but not foolproof. The injectable typhoid vaccine is about 50–80% effective, while the oral vaccine provides around 60–80% protection. Both vaccines reduce the severity of illness if you do get infected.

    Because protection wanes over time, booster doses are recommended every 2–5 years for ongoing risk. While the vaccine lowers your chances of getting sick, it’s important to also practice safe food and water habits, especially when traveling. Avoid raw produce, street food, and unfiltered water to maximize your protection.

    Where to get the typhoid vaccine

    You can get the typhoid vaccine at travel clinics, select pharmacies, urgent care centers, and primary care providers. It’s best to schedule your appointment at least 2–4 weeks before travel to high-risk areas. Solv makes it easy to find and book a same-day typhoid vaccine appointment near you.

    Where to get the typhoid vaccine

    Other common travel vaccines

    Before traveling internationally, it’s important to protect yourself against diseases that may be rare in the U.S. but common elsewhere. Vaccination can help prevent serious illness and is often required for entry into certain countries. Below are some of the most common travel vaccines and who should consider them based on destination.

    FAQs

    • Who should not get the typhoid vaccine?

      Individuals with a severe allergic reaction to a component of the vaccine, those who are currently ill, or those with weakened immune systems should consult a healthcare provider before getting vaccinated.

    • What are the side effects of the typhoid vaccine?

      Common side effects include pain at the injection site, fever, headache, and gastrointestinal discomfort. Serious side effects are rare.

    • What other vaccines can be given with the typhoid vaccine?

      The typhoid vaccine can be given alongside other vaccines, such as the hepatitis A vaccine and routine immunizations, but it’s best to consult a healthcare provider for personalized advice.

    • What causes typhoid fever?

      Typhoid fever is caused by the bacterium Salmonella enterica serotype Typhi, which is typically transmitted through contaminated food and water.

    • What are the symptoms of typhoid fever?

      Symptoms include prolonged fever, weakness, abdominal pain, headache, loss of appetite, and sometimes a rash.

    • How long does typhoid fever last?

      Without treatment, typhoid fever can last several weeks to months. With appropriate antibiotic treatment, symptoms usually improve within a few days.

    • What does typhoid rash look like?

      The typhoid rash, known as "rose spots," appears as small, pinkish spots on the abdomen and chest and may also be faintly raised.

    • Where does typhoid fever occur?

      Typhoid fever is most commonly found in areas with poor sanitation and hygiene, particularly in parts of South Asia, Africa, and Latin America.

    • How does typhoid fever spread?

      Typhoid fever spreads primarily through ingestion of food or water contaminated with S. Typhi, often due to poor sanitation practices.

    • How is typhoid fever treated and prevented?

      Typhoid fever is treated with antibiotics, and prevention includes vaccination, good hygiene practices, and safe food and water consumption.

    • Is there a cure for typhoid fever?

      Yes, typhoid fever can be effectively treated with antibiotics, although antibiotic resistance can complicate treatment.

    • Do I need a prescription for the typhoid vaccine?

      In most cases, a prescription is not required to receive the typhoid vaccine, but it’s advisable to consult a healthcare provider.

    • When should I get the typhoid vaccine before my trip?

      It is recommended to get vaccinated at least 2 weeks before traveling to areas where typhoid fever is prevalent.

    • How much does the typhoid vaccine cost?

      The cost of the typhoid vaccine can vary widely, typically ranging from $30 to $100, depending on the provider and location.

    • How long does the typhoid vaccine last?

      The injectable vaccine provides typhoid protection for about 2 years, while the oral vaccine lasts approximately 5 years.

    • Do I need a typhoid vaccine booster?

      Yes, boosters are recommended for those at ongoing risk of exposure, typically every 2 years for the injectable vaccine and every 5 years for the oral vaccine.

    • Where can I get the typhoid vaccine?

      The typhoid vaccine is available at healthcare providers, travel clinics, and some pharmacies.

    Dr. Rob Rohatsch, MD, is a Board-Certified Emergency Medicine physician and urgent care executive. He earned his MD from Jefferson Medical College, currently serves on multiple boards and is Solv’s Chief Medical Officer.

    How we reviewed this article

    Medically reviewed

    View this article’s sources and history, and read more about Solv’s Content Mission Statement, editorial process, and editorial team.

    Sources

    3 sources

    Solv has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.

    • Typhoid Vaccine VIS. (March 12, 2025)
    • Preventing Typhoid Fever and Paratyphoid Fever (April 25, 2024)
    • Typhoid (March 25, 2025)

    3 sources

    Solv has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.

    • Typhoid Vaccine VIS. (March 12, 2025)
    • Preventing Typhoid Fever and Paratyphoid Fever (April 25, 2024)
    • Typhoid (March 25, 2025)
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